DengueNS1

INTRODUCTION

Dengue NS1&IgG/IgM is a combined rapid immunochromatographic test for the qualitative detection of dengue virus NS1 antigen in human serum/plasma for early diagnosis of acute infection and for the qualitative and differential detection of IgG and IgM in human serum/plasma/whole blood. Dengue virus belongs to Flaviviridae family, common in tropical and sub-tropical regions, which is found in four distinct serotypes (1, 2, 3 and 4). Dengue fever is transmitted by mosquitoes, of the species Aedes aegypti and Aedes albopictus. Primary dengue infection results mostly in a self-limiting mild to high fever, while secondary infection is more common and potentially fatal resulting in severe conditions like Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). The following table gives the duration for detectable rise in NS1 antigen, IgG and IgM antibodies in blood in cases of primary and secondary infections:
Ag/Ab Primary Infection Secondary Infection
NS1 1-9 days upto 15 days 1-9 days
IgM 5-10 days 4-5 days
IgG 14 days till lifetime 1-2 days
NS1 antigen appears from day 1 in blood and helps in early diagnosis which reduces risks of complications. Combining the detection of NS1, IgG and IgM in this rapid diagnostic test ensures that all stages from acute to convalescence phase of the disease are covered.

 PRINCIPLE:

The Dengue NS1&IgG/IgM test consists of two devices: one for the detection of Dengue NS1 antigen and second one for the differential detection of Dengue IgG/IgM antibodies in human serum/plasma/whole blood.
Instructions for Use:
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